Electric Fields Due to Synaptic Currents Sharpen Excitatory Transmission
نویسندگان
چکیده
منابع مشابه
Electric fields due to synaptic currents sharpen excitatory transmission.
The synaptic response waveform, which determines signal integration properties in the brain, depends on the spatiotemporal profile of neurotransmitter in the synaptic cleft. Here, we show that electrophoretic interactions between AMPA receptor-mediated excitatory currents and negatively charged glutamate molecules accelerate the clearance of glutamate from the synaptic cleft, speeding up synapt...
متن کاملSynaptic adhesion molecules and excitatory synaptic transmission
Synaptic adhesion molecules have been extensively studied for their contribution to the regulation of synapse development through trans-synaptic adhesions. However, accumulating evidence increasingly indicates that synaptic adhesion molecules are also involved in the regulation of excitatory synaptic transmission and plasticity, often through direct or close associations with excitatory neurotr...
متن کاملNoradrenergic System Increases Miniature Excitatory Synaptic Currents in the Barrel Cortex
Introduction: Neurons in layer II and III of the somatosensory cortex in rats show high frequency (33 ± 13 Hz) of miniature excitatory postsynaptic currents (mEPSCs) that their rates and amplitudes are independent of sodium channels. There are some changes in these currents in neurodegenerative and psychological disorders. Regarding to well known roles of the neuromodulatory brain systems in...
متن کاملSynaptic Transmission: Excitatory Autapses Find a Function?
An autapse is a synapse between a neuron and itself, a peculiar structure with an unclear function. A new study suggests that excitatory autapses contribute to a positive-feedback loop that maintains persistent electrical activity in neurons.
متن کاملnoradrenergic system increases miniature excitatory synaptic currents in the barrel cortex
introduction: neurons in layer ii and iii of the somatosensory cortex in rats show high frequency (33 ± 13 hz) of miniature excitatory postsynaptic currents (mepscs) that their rates and amplitudes are independent of sodium channels. there are some changes in these currents in neurodegenerative and psychological disorders. regarding to well known roles of the neuromodulatory brain systems in th...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Science
سال: 2008
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1154330